Table II.

GO terms of DEGs.

A, The top 10 GO terms of the 132 upregulated DEGs
Category	Term	Count	P-value	Genes
GO:0046649	Lymphocyte activation	24	1.49×10−11	GAPT, TCF7, CR2, IGHM
GO:0045321	Leukocyte activation	25	4.68×10−11	GAPT, TCF7, CR2, IGHM
GO:0002684	Positive regulation of immune system process	27	2.66×10−10	BLK, CR2, IGHM, PRKCB
GO:0050778	Positive regulation of immune response	23	3.37×10−10	CR2, IGHM, PRKCB, CARD11
GO:0006955	Immune response	33	1.46×10−9	IL16, BLK, PAX5, GPRC5B
GO:0002376	Immune system process	42	2.11×10−9	IL16, BLK, PAX5, GPRC5B
GO:0001775	Cell activation	25	2.52×10−9	GAPT, TCF7, CR2, IGHM
GO:0002682	Regulation of immune system process	30	6.97×10−9	BLK, CR2, IGHM, PRKCB
GO:0050776	Regulation of immune response	24	1.34×10−8	CR2, IGHM, PRKCB, CARD11
GO:0042113	B cell activation	13	6.02×10−8	GAPT, CR2, IGHM, PRKCB
B, Top 10 GO terms of the 198 downregulated DEGs
Category	Term	Count	P-value	Genes
GO:0042445	Hormone metabolic process	10	5.45×10−5	STARD3, TG, ALDH8A1, FOXA1
GO:0044699	Single-organism process	143	4.38×10−4	PDP1, ALDH8A1, ADCY1, TSPAN1
GO:0034754	Cellular hormone metabolic process	7	5.22×10−4	STARD3, ALDH8A1, SRD5A3, CACNA1H
GO:0010817	Regulation of hormone levels	14	5.62×10−4	ALDH8A1, TG, FOXA1, IYD
GO:0009952	Anterior/posterior pattern specification	9	6.17×10−4	HOXC10, MSX2, PCGF2, HOXC11