Table II.

Cox regression analysis of prognostic factors for overall survival in patients with colorectal cancer.

	Univariate			Multivariate
Variable	HR	CI (95%)	P-value	HR	CI (95%)	P-value
Sex	1.137	0.713–1.936	0.372
Age	0.765	0.536–1.821	0.427
Tumor size	0.634	0.345–1.176	0.425
Tumor location	0.213	0.819–2.778	0.719
Differentiation	0.729	0.467–1.306	0.116
Depth of invasion	3.231	1.312–5.832	0.034	1.442	0.845–1.886	0.676
Lymph node metastasis	3.509	2.399–5.442	0.004	2.123	1.371–4.734	0.002
Distant metastasis	5.738	3.548–8.536	0.002	3.631	2.514–6.722	0.001
AJCC stage	3.448	2.928–6.335	0.021	1.693	1.021–4.561	0.027
FLOT2 expression	4.485	2.375–7.488	0.001	2.987	0.962–5.135	0.013

HR, hazard ratio; CI, confidence interval; AJCC, American Joint Committee on Cancer; FLOT2, flotillin 2.