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Spiropyrazolines oxindoles screen in HCT116 human colorectal carcinoma cells. HCT116 p53(+/+) and HCT116 p53(−/−) cells were exposed to spiropyrazoline oxindoles 1a–r or vehicle (DMSO) at 12.5 μM for 72 h. Cell metabolism was evaluated by MTS assay. Results are expressed as mean ± SEM fold-change to vehicle treated cells from one experiment performed in duplicates. Dashed line represents vehicle control results.
