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. 2019 Jan 7;11(2):e9665. doi: 10.15252/emmm.201809665

Figure 7. Stat3 deletion in astrocytes protects from spatial memory and learning deterioration.

Figure 7

  • A
    Spatial learning and memory were assessed in the Morris Water Maze paradigm. APP/PS1‐Stat3KO mice showed faster latencies to reach the hidden platform compared with APP/PS1‐Stat3WT on days 4 and 5, but were similar to WT‐Stat3WT and WT‐Stat3KO mice (*P < 0.05, two‐way repeated‐measures ANOVA followed by Bonferroni post hoc test; P‐values are for APP/PS1‐Stat3KO versus APP/PS1‐Stat3WT mice).
  • B
    The area under the curve (AUC) for the latency to reach the hidden platform was similar in APP/PS1‐Stat3WT compared to WT‐Stat3WT and WT‐Stat3KO mice, but significantly higher in APP/PS1‐Stat3KO mice (*P < 0.05, Kruskal–Wallis test followed by Dunn's multiple comparisons test).
  • C
    The swimming velocity was similar in all groups (Kruskal–Wallis test followed by Dunn's multiple comparisons test).
  • D, E
    In the probe trial 24 h after the last training day, the time mice spent in the target quadrant (TQ) was different from chance in all groups except for APP/PS1‐Stat3WT mice (P < 0.05, one‐tailed one‐sample t‐test). APP/PS1‐Stat3KO, WT‐Stat3WT, and WT‐Stat3KO mice spent significantly more time in the target quadrant compared to the mean of all other quadrants (AO), whereas APP/PS1‐Stat3WT spent equal times in the target and all other quadrants (*P < 0.05, Wilcoxon matched‐pairs signed rank test for each comparison).
Data information: Data are represented as mean ± SEM. WT‐Stat3WT, n = 15 (7 females and 8 males) mice; WT‐Stat3KO, n = 15 (10 females and 5 males) mice; APP/PS1‐Stat3WT, n = 15 (eight females and seven males) mice; APP/PS1‐Stat3KO, n = 15 (nine females and six males) mice; age, 8–9 months).