Table 3.
Effects of digoxin on the sensitivity of SW1990/Gem and Panc-1/Gem cells to different anticancer drugs.
| Group | SW1990/Gem |
Panc-1/Gem |
|||
|---|---|---|---|---|---|
| IC50 | RF | IC50 | RF | ||
| Gemcitabine (μM) | Control | 519.59 ± 31.14 | 1 | 283.47 ± 21.7 | 1 |
| Digoxin 20 nM | 98.55 ± 6.12 | 5.27 | 72.47 ± 6 | 3.91 | |
| Digoxin 40 nM | 37.18 ± 4.75 | 13.97 | 39.54 ± 4.61 | 7.17 | |
| Digoxin 80 nM | 14.5 ± 2.03 | 35.83 | 13.87 ± 2.16 | 20.43 | |
| Etoposide (μM) | Control | 633.19 ± 40.77 | 1 | 445.82 ± 30.85 | 1 |
| Digoxin 20 nM | 445.77 ± 22.04 | 1.42 | 327.28 ± 20.82 | 1.36 | |
| Digoxin 40 nM | 232.98 ± 18.38 | 2.72 | 172.46 ± 10.57 | 2.59 | |
| Digoxin 80 nM | 110.95 ± 13.63 | 5.71 | 119.34 ± 12.85 | 3.74 | |
| Paclitaxel (nM) | Control | 293.07 ± 19.72 | 1 | 216.53 ± 16.27 | 1 |
| Digoxin 20 nM | 209.57 ± 17.65 | 1.4 | 144.27 ± 11.57 | 1.5 | |
| Digoxin 40 nM | 61.04 ± 4.99 | 4.8 | 67.82 ± 4.05 | 3.19 | |
| Digoxin 80 nM | 35.77 ± 4.31 | 8.19 | 37.01 ± 4.99 | 5.85 | |
| Cisplatin (μM) | Control | 186.47 ± 11.41 | 1 | 155.53 ± 11.78 | 1 |
| Digoxin 20 nM | 112.87 ± 8.52 | 1.65 | 107.17 ± 7.35 | 1.45 | |
| Digoxin 40 nM | 86.24 ± 6.39 | 2.16 | 68.15 ± 6.24 | 2.28 | |
| Digoxin 80 nM | 51.73 ± 6.28 | 3.6 | 58.44 ± 6.06 | 2.66 | |
| 5-FU (μM) | Control | 185.38 ± 14.67 | 1 | 168.39 ± 10.8 | 1 |
| Digoxin 20 nM | 118.23 ± 10.08 | 1.57 | 110.88 ± 7.6 | 1.52 | |
| Digoxin 40 nM | 86.55 ± 7.17 | 2.14 | 73.46 ± 7.73 | 2.29 | |
| Digoxin 80 nM | 55.25 ± 7.06 | 3.36 | 38.89 ± 4.72 | 4.33 | |
| Ara-C (μM) | Control | 16.88 ± 1.15 | 1 | 10.93 ± 0.96 | 1 |
| Digoxin 20 nM | 11.4 ± 1.07 | 1.48 | 8.5 ± 0.74 | 1.29 | |
| Digoxin 40 nM | 6.65 ± 0.5 | 2.54 | 4.66 ± 0.3 | 2.35 | |
| Digoxin 80 nM | 2.99 ± 0.32 | 5.65 | 1.61 ± 0.33 | 6.79 | |
| Doxorubicin (μM) | Control | 29.24 ± 2.74 | 1 | 24.4 ± 1.84 | 1 |
| Digoxin 20 nM | 14.03 ± 1.54 | 2.08 | 15.02 ± 1.68 | 1.62 | |
| Digoxin 40 nM | 11.06 ± 1.19 | 2.64 | 10.82 ± 1.16 | 2.26 | |
| Digoxin 80 nM | 6.74 ± 0.47 | 4.34 | 7.52 ± 0.92 | 3.24 | |
Effects of digoxin on the sensitivity of SW1990/Gem and Panc-1/Gem cells to different anticancer drugs were detected by MTT assay. Data were expressed as mean ± SD of three independent experiments.