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. 2019 Jan 31;10:42. doi: 10.3389/fmicb.2019.00042

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Copyright © 2019 Gianvecchio, Lozano, Henderson, Kalhori, Bullivant, Valencia, Su, Bello, Wong, Cook, Fuller, Neal and Yeh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of the Mutant Selection Window. As antibiotic concentrations increase, the percentage of colonies recovered decreases with two sharp declines demarcating the boundaries of the mutant selection window (MSW), in red. The shaded region selects for single-step resistant mutants. The first decline, which results in a 99% decrease in colonies recovered is determined to be the minimum inhibitory concentration (MIC). The second decline, where there is a 100% decrease in colonies recovered is determined to be the mutation prevention concentration (MPC).