Figure 2.

CFA-induced mechanical & thermal hypersensitivity and paw edema in B6J and B6N mice. Differences in (A) mechanical paw withdrawal thresholds and (B) paw withdrawal latencies (Δ PWL=contralateral–ipsilateral hindpaw latencies) in B6J and B6N mice at different times after injection of complete Freund's adjuvant (CFA, 10 % solution/20 µl). Degree of edema (C), as measured by the difference in the ipsilateral paw diameter before and after injection (ΔPD) in B6J and B6N mice. Data are expressed as the mean ± S.E.M. of 6 mice/per sex/per group. *p<0.05 significantly different from the value of baseline (BL).