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. 2019 Feb 4;13:1753466618820186. doi: 10.1177/1753466618820186

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© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure A2. — DSA tornado diagram: lumacaftor/ivacaftor + SC versus SC alone.

ppFEV₁, percent predicted forced expiratory volume in 1 second; PEx, pulmonary exacerbation; SC, standard care.

*When all age-dependent ppFEV1 annual rates of decline are increased, both the LUM/IVA and SC rates of decline increase, leading to lower survival in both groups and reduced incremental survival vs. the base-case; when the rates are reduced, survival increases for both LUM/IVA and SC but in this case incremental survival is also reduced vs. the base-case.