Table 2.

Knowledge advancement on the topic

Outcome	Cochrane Meta-analysis 2015 [9]a	Present work
Mortality	Favours poractant-α (for some types of mortality)b	Trend favouring poractant-α
BPD	No difference	Favours poractant-α
Airleaks	No difference	Favours poractant-α
Lung haemorrhage	No difference	Favours poractant-α
BPD/mortality	Favours poractant-α	Favours poractant-α
Re-treatment	Unknown or favours poractant-αc	Favours poractant-α
Effect of confounder	Cochrane Meta-analysis 2015	Present work
Prenatal steroids	Unknown	Not significant
Gestational age	Unknown	Influences effect size on BPD and need for retreatment
Poractant-α dose	Unknown	Unknown

Conclusions from the present work and the earlier meta-analysis [9] are compared. New insights are in italic texts

^aincluding both the comparisons lavage bovine and minced bovine vs minced porcine surfactant - ^b only for in-hospital mortality. The overall neonatal mortality did not present any difference - ^c This outcome was analysed only for the comparison bovine minced vs porcine minced surfactants