Table 1.
Examples of different flavonoids targeting PI3k/Akt/mTOR pathway in different cell lines.
| Flavonoid | Duration | Cell line | Effect | References |
|---|---|---|---|---|
| Fisetin | 24/48 h | Lung carcinoma cell line | Inhibition of tumor cell growth Increased activation of PTEN, AMPK, and TSC2 Decreased activity of PI3K, Akt, and mTOR | (25) |
| Fisetin | 24/48 h | Prostate cell line | Induction of apoptosis Induction of caspase 3, 8, and 9 activity Decreased activity of Cyclins, CDKs, PI3K, Akt | (98) |
| Gelam honey and ginger | 24/48 h | Colon cell line | Inhibition of cell viability | (99) |
| Pomegranate | 24 h | Colon cell line | mTOR, Akt and PI3k activity suppression and decreased expression | (100) |
| Curcumin | 2 h | Colorectal cell line | Decreased mTOR and Akt expression | (101) |
| Quercetin | 24/48 h | Prostate cell line | Suppression of mTOR and Akt activity | (102) |
| Baicalein | 72 h | Prostate cell line | Induction of apoptosis in cancer cells mTOR and Akt activation decreased | (103) |
| Butein | 24 h | Cervical cell line | Induction of G2/M arrest Induction of caspase 3, 8, and 9 activity Decreased activity of PI3K, Akt, and mTOR | (104) |