Fig. 2.

The joint LR is the product of individual LRs according to the naïve Bayesian scheme. The joint LR represents the quantitative prediction of functional association between two genes. Individual LRs were calculated from six genomic features: gene coexpression, semantic similarity in GO Biological Process, phylogeny similarity, protein domain similarity, OMIM phenotype similarity, and essential genes. An individual LR is omitted from the joint LR calculation if a genomic feature for the gene pair is missing.