Table 2.

Significant GO SLIM terms enriched in the top 100 most connected genes in the HFOnet.^a

GO term	GO name	Hypergeometric P valueb
Biological process
GO:0043170	Macromolecule metabolic process	2.07E-18
GO:0007154	Cell communication	5.07E-17
GO:0008152	Metabolic process	3.11E-14
GO:0050789	Regulation of biological process	1.22E-13
GO:0009987	Cellular process	2.15E-13
GO:0030154	Cell differentiation	0.00039519
GO:0050896	Response to stimulus	0.000418585
GO:0008219	Cell death	0.005115639
Molecular function
GO:0016301	Kinase activity	1.24E-53
GO:0016740	Transferase activity	3.98E-41
GO:0003824	Catalytic activity	2.17E-17
GO:0005488	Binding	6.56E-12
GO:0005515	Protein binding	4.59E-09
GO:0004871	Signal transducer activity	0.002071487

^aThe top 100 most connected genes all have more than 400 directly linked neighbors, and the HFOnet was defined by joint LR > 528.

^bGO term significance was defined by hypergeometric P < 0.01.