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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: J Thorac Oncol. 2018 Jul 4;13(10):1483–1495. doi: 10.1016/j.jtho.2018.06.016

Figure 2.

Figure 2.

Chromosomal Position, Gene Exon, Protein Domain(s), and the Top Candidates

A. LTB p.Leu87Phe located in the 3rd exon, the β-strand which links the Transmembrane and TNF domains;

B. P3H2 p.Gln185His located in the 2nd exon, between the 2nd and 3rd Tetratricopeptide-like helical repeat (TPR) domains;

C. DAMM2 p.Asp762Gly located the 18th exon, the 2nd Formin Homology (FH) domain.

The top candidate mutations were indicated with red lines in the chromosome and gene exons (genomic location, assembly GRCh37), and red arrows in the protein. The gene annotation also shows forward (DAMM2) or reverse (LTB and P3H2) strand of the chromosome.