Table 1.
Basic Characteristics of LC Cases and Controls in the Discovery and Validations
| Characteristics | Discovery | Validation: WSU Study | Validation: TRICL-ILCCO Study | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Case (n = 260) * |
Smoking control (n = 318) # |
P value & | Case (n = 831) |
Smoking control (n = 266) # |
P value & | Case (n = 942) |
Control (n = 857) # |
P value & | |
| Age, year | |||||||||
| Mean (SD) | 64 (6.3) | 62.6 (4.9) | 0.258 | 63.6 (9.8) | 59.5 (9.1) | <0.001 | 62.4 (12.3) | 60.8 (11.8) | 0.006 |
| Range | 30 - 87 | 55 - 80 | 31 - 88 | 35 - 86 | 23.8 - 91 | 19.8 - 90 | |||
| Sex | |||||||||
| Male (%) | 165 (63.4) | 172 (54.1) | 0.039 | 398 (47.9) | 129 (48.5) | 0.920 | 515 (54.7) | 498 (58.1) | 0.15 |
| Female (%) | 95 (39.7) | 146 (45.9) | 433 (52.1) | 137 (51.5) | 427 (45.3) | 359 (41.9) | |||
| Smoking status | |||||||||
| Never (%) | 21 (8.1) | - | <0.001 | - | - | <0.001 | 108 (11.5) | 303 (35.6) | <0.001 |
| Former (%) | 163 (62.7) | 156 (49.1) | 372 (44.8) | 153 (57.5) | 380 (40.4) | 357 (41.9) | |||
| Current (%) | 76 (29.2) | 162 (50.9) | 459 (55.2) | 113 (42.5) | 450 (47.9) | 194 (22.5) | |||
| Smoking pack-years | <0.001 | ||||||||
| Mean (SD) | 45.5 (32.9) | 53.6 (18.4) | <0.001 | 51.8 (30.0) | 35.3 (20.5) | <0.001 | 42.6 (28.0) | 22.8 (18.6) | - |
| Range | 0-165 | 10 - 97 | 10 - 216 | 10 – 124 | 0-196 | 0-105 | |||
| FEV1 (% pred) # | |||||||||
| Mean (SD) | 69.1 | 93.9 (10.5) | <0.001 | 68.6 (20.4) | 94.5 (10.3) | <0.001 | - | - | - |
| Range | 22-124 | 80 - 129.1 | 15 - 135.1 | 80 - 123.2 | - | - | |||
| FEV1/FVC # | |||||||||
| Mean (SD) | 0.59 | 0.77 (0.05) | <0.001 | 0.66 (0.12) | 0.79 (0.04) | < 0.001 | - | - | - |
| Range | 0.27-0.94 | 0.70 - 0.9 | 0.27-0.97 | 0.70-0.94 | - | - | |||
| Histology | |||||||||
| Adenocarcinoma | 136 (52.3) | - | - | 415 (51.3) | - | - | 325 (44.3) | - | - |
| Squamous | 82 (31.5) | - | 176 (21.8) | - | 248 (33.8) | - | |||
| Other | 42 (16.2) | - | 218 (26.9) | - | 161 (21.9) | - | |||
*
Of the 260 LC cases, 54 were unrelated familial cases; and 75 out of the 206 sporadic LC cases also had severe COPD.
#
Controls with normal pulmonary function are defined as FEV1 > 80% and FEV1/FVC > 0.7 predicted. These data are not available for familial cases in the discovery and the TRICL-ILCCO study subjects.
&
P value from the two-sided chi-square test (for categorical variables) and Student’s t test (for continuous variables).