Fig A3.

miR-34A promoter methylation across multiple histologic sections of tumor and normal tissue in patients who harbor germline mutations in TP53. (A) Methylation levels at three CpG sites on the miR-34A promoter CpG island labeled in red in the sequence provided across multiple histologic sections of tissue from patient donor 4264. The first CpG site corresponds to cg12385729. (B) miR-34A promoter methylation levels as in (A) for tissue from patient donor 4115 as well as choroid plexus carcinoma tumor DNA from the patient's male sibling.