Table 1.
The permeability and perfusion characteristic of MS lesions and NAWM regions
| Index | CE | NE | Near NAWM | Far NAWM | χ2 value | P-value |
|---|---|---|---|---|---|---|
|
| ||||||
| Ktrans | 0.2148 (0.0488–0.4525) | 0.0326 (0.0195–0.0716) | 0.0456 (0.0195–0.0716) | 0.0456 (0.0195–0.0781) | 26.847 | 0.000 |
| Vp | 0.2448 (0.1758–0.3626) | 0.0352 (0.0195–0.0768) | 0.0273 (0.0143–0.0468) | 0.0299 (0.0143–0.0508) | 64.271 | 0.000 |
| CBF | 45.5483 (32.9309–61.3355) | 6.8000 (4.3279–11.4639) | 6.0588 (4.3205–11.2014) | 6.272 (4.4487–10.4447) | 69.547 | 0.000 |
| CBV | 39.787 (29.0745–61.6703) | 5.8584 (4.0404–10.9631) | 5.1239 (4.1287–9.9228) | 5.1210 (4.0478–9.4874) | 68.930 | 0.000 |
Notes: Median (P25–P75) was used to describe the permeability and perfusion characteristic of MS lesions and NAWM regions. Near NAWM: NAWM regions close to lesions. Far NAWM: NAWM regions far from the lesions. Ktrans: min−1, Vp: (mL⋅100 g−1), CBF: (mL⋅100 g−1⋅min−1), CBV: (mL⋅100 g−1).
Abbreviations: CBF, cerebral blood flow; CE, contrast-enhancing; CBV, cerebral blood volume; Ktrans, volume transfer constant; MS, multiple sclerosis; NAWM, normal-appearing white matter; NE, non-enhancing; Vp, fractional plasma volume.