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Reversibility of the inhibition of hMAO-B by 37. hMAO-B and 37 (at 4 × IC50) were preincubated for 15 min, dialyzed for 24 h and the residual enzyme activity was measured (37, dialyzed). hMAO-B was similarly preincubated in the absence (No Inh, dialyzed) and presence of the irreversible inhibitor, (R)-(−)-deprenyl (depr, dialyzed), and dialyzed. For comparison, the residual hMAO activity of undialysed mixtures of hMAO-B with 37 is also shown (37, not dialyzed).
