Table 1.

Inhibition data against bacterial, diatom, fungal, protozoan, insect and human CAs with famotidine (FAM) and acetazolamide (AAZ) by a stopped flow CO₂ hydrase assay²².

KI (nM)*
	Organism	Enzyme class	FAM	AAZ
VchCAα	Bacterium	Α	72.3	6.8
VchCAβ	Bacterium	Β	83917	451
VchCAγ	Bacterium	Γ	5321	473
SspCA	Bacterium	Α	230	4.5
SazCA	Bacterium	Α	124	0.9
Rv3274	Bacterium	Β	1265	104
BpsCAβ	Bacterium	Β	8271	745
BpsCAγ	Bacterium	Γ	8293	149
PhaCAγ	Bacterium	Γ	66.8	403
CpsCAγ	Bacterium	Γ	89.0	502
NcoCAγ	Cyanobacterium	Γ	1695	75.8
TweCAδ	Diatom	Δ	408	83
TweCA Cd	Diatom	Ζ	90.7	69
TweCA Zn	Diatom	Ζ	22.1	58
MgaCA	Fungus	Β	42109	40000
Can2	Fungus	Β	107	10.5
CgNce103	Fungus	Β	13.6	11
TcCA	Protozoan	Α	5707	61.6
PfCA	Protozoan	η	142	170
AgaCA	Insect	Β	397	26
hCA I**	Human	Α	922	250
hCA II**	Human	Α	58.0	12.1

*Mean from three different assays, by a stopped flow technique (errors were in the range of ±5–10% of the reported values).

**From Ref.²⁶.