Table 1.

Drivers of Hospitalizations and Mortality Related to Complications of CLD

	Annual Incidence Trend	Prevalence (Trend)	Relative Risk (Trend)	PAF	Prevention (efficacy/ effectiveness)	Treatment (efficacy/ effectiveness)
HCV	Declined but recent outbreaks	1%–2% (declining)	20 (declining)	20%–30%	++/++	+++/++
HBV	Declining	0.5% (declining)	20 (declining)	5%–10%	+++/++	++/++
Alcoholic liver disease	Rising	5%–10% (stable)	2 (stable/ increasing)	20%–30%	++/+	++/+
NAFLD	Rising	10%–30% (increasing)	1.5–2.0 (increasing)	25%–35%	−/−	+/−

CLD, chronic liver disease; HBV, hepatitis B virus; HCV, hepatitis C virus; NAFLD, nonalcoholic fatty liver disease; PAF, population-attributable fraction.