Fig. 4.

The normal reproductive morphology of miR-34b/c/Pten DKO mice. A and B) The ovaries (black arrows), oviducts (black arrowheads), and uteri (yellow arrows) from miR-34b/c^−/−/Pten^fl/fl/Amhr2^cre/+ mice look grossly normal (12–13 mo old). C and D) Histologically, the ovaries of these mice show a normal morphology with preantral and antral follicles displayed at different stages, as well as with corpora lutea (asterisks) (H&E; original magnification ×4). E and F) Cross-sectional views of miR-34b/c^−/−/Pten^fl/fl/Amhr2^cre/+ mouse oviducts displaying a typical normal histology of the mouse oviduct (H&E; original magnification ×10).