Table III.
Coefficients and standard error estimates (SE), odds ratios (OR) and 95% confidence intervals (CI) for early menopause by level of anti-Müllerian hormone (AMH) among cases (n = 327) and all controls (n = 491), stratified by potential effect modifiers, Nurses' Health Study II, 1996–2011.
| No change in menstrual cyclea | Change in menstrual cyclea | ||
|---|---|---|---|
| n = 119 cases versus 251 controls | n = 147 versus 167 | ||
| Coefficient (SE)b | Coefficient (SE)b | P intc | |
| AMH (per 0.10 ng/ml lower) | 0.216 (0.03)d | 0.308 (0.04)d | <0.001 |
| AMH*AMH | 0.0011 (0.0002)d | 0.0036 (0.0007)d | |
| AMH (ng/ml) | OR (95% CI)e | OR (95% CI)e | |
| 2.00 | Ref | Ref | |
| 1.50 | 2.4 (1.9–3.1) | 2.5 (2.0–3.1) | |
| 1.00 | 6.3 (3.9–10) | 7.3 (4.4–12) | |
| 0.50 | 17 (8.1–36) | 26 (11–59) | |
| Never smoker | Ever smoker | ||
| n = 222 vs. 322 | n = 105 vs. 169 | ||
| Coefficient (SE)b | Coefficient (SE)b | Pintc | |
| AMH (per 0.10 ng/ml lower) | 0.199 (0.02)d | 0.386 (0.06)d | 0.006 |
| AMH*AMH | 0.0012 (0.0001)d | 0.0046 (0.0009)d | |
| AMH (ng/ml) | OR (95% CI)e | OR (95% CI)e | |
| 2.00 | Ref | Ref | |
| 1.50 | 2.2 (1.9–2.6) | 3.1 (2.2–4.3) | |
| 1.00 | 5.2 (3.6–7.4) | 12 (5.7–25) | |
| 0.50 | 13 (7.4–22) | 58 (17–197) | |
| BMI < 25 kg/m2 | BMI ≥ 25 kg/m2 | ||
| n = 204 vs. 306 | n = 123 vs. 185 | ||
| Coefficient (SE)b | Coefficient (SE)b | Pintc | |
| AMH (per 0.10 ng/ml lower) | 0.226 (0.03)d | 0.271 (0.04)d | 0.004 |
| AMH*AMH | 0.0012 (0.0002)d | 0.0026 (0.0005)d | |
| AMH (ng/ml) | OR (95% CI)e | OR (95% CI)e | |
| 2.00 | Ref | Ref | |
| 1.50 | 2.5 (2.0–3.1) | 2.5 (1.9–3.1) | |
| 1.00 | 6.7 (4.4–10) | 6.8 (4.1–12) | |
| 0.50 | 19 (9.9–37) | 22 (9.5–50) | |
| No history of infertility | History of infertility | ||
| n = 240 vs. 371 | n = 87 vs. 120 | ||
| Coefficient (SE)b | Coefficient (SE)b | Pintc | |
| AMH (per 0.10 ng/ml lower) | 0.234 (0.02)d | 0.277 (0.05)d | 0.002 |
| AMH*AMH | 0.0012 (0.0002)d | 0.0033 (0.0009)f | |
| AMH (ng/ml) | OR (95% CI)e | OR (95% CI)e | |
| 2.00 | Ref | Ref | |
| 1.50 | 2.6 (2.1–3.1) | 2.2 (1.7–2.9) | |
| 1.00 | 7.2 (4.8–11) | 6.0 (3.3–10.6) | |
| 0.50 | 21 (11–39) | 19 (7.1–49) |
aParticipant report whether menstrual cycle length, regularity and pattern has changed since they were in their 20s; excludes women using exogenous hormones.
bUnconditional logistic regression modeling, adjusted for matching factors: age (months), fasting status, time of day of blood collection, season and analytic batch
cP values for interaction from likelihood ratio test comparing models with and without interaction terms.
dP < 0.001.
eOR and 95% CI for early menopause comparing range of AMH values to the referent of 2.0 ng/ml, based on coefficient estimates for AMH + AMH*AMH.
fP < 0.01.