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5-Aza reversed hypoxia-induced reduction of BKCa channel-mediated relaxations of uterine arteries. Uterine arteries were isolated from low-altitude pregnant animals and were treated ex vivo with 21.0% O2 and 10.5% O2 for 48 h in the absence (A) or presence (B) of 5-Aza (10.0 μM). Uterine arteries were contracted with serotonin (1 μM) followed by additions of NS1619. Data are mean ± SEM of tissues from six to eight animals of each group. *P < 0.05, 10.5% O2 vs. 21.0% O2.
