Table 4.
Correlations of mitral annular 18F-fluoride and 18F-FDG PET uptake (disease activity) with imaging findings in the mitral annulus (local factors) and remote regions, as well as serum biomarker levels (remote factors)
| 18F-fluoride TBRmax | 18F-FDG TBRmax | |||
|---|---|---|---|---|
| r | p | r | p | |
| Local Factors | ||||
| Mitral annulus CT calcium score | 0.78 | <0.001 | 0.50 | <0.001 |
| Mitral annulus 18F-fluoride TBRmax | - | - | 0.54 | <0.001 |
| Mitral annulus 18F-FDG TBRmax | 0.54 | <0.001 | - | - |
| Remote Factors | ||||
| Aortic valve CT calcium score | 0.24 | 0.017 | 0.15 | 0.218 |
| Aortic valve 18F-fluoride TBRmax | 0.19 | 0.053 | -0.02 | 0.848 |
| Aortic valve 18F-FDG TBRmax | -0.02 | 0.895 | -0.05 | 0.658 |
| Coronary artery CT calcium score | 0.03 | 0.789 | 0.12 | 0.327 |
| Coronary artery 18F-fluoride TBRmax | 0.14 | 0.159 | 0.08 | 0.518 |
| Aorta CT calcium score | 0.20 | 0.049 | 0.14 | 0.262 |
| Aorta 18F-fluoride TBRmax | 0.23 | 0.025 | -0.02 | 0.884 |
| Aorta 18F-FDG TBRmax | -0.16 | 0.127 | -0.23 | 0.060 |
| Bone mineral density | -0.19 | 0.065 | -0.15 | 0.247 |
| Bone 18F-fluoride TBRmax | 0.02 | 0.861 | 0.01 | 0.989 |
| Serum biomarkers | ||||
| Calcium | 0.15 | 0.126 | 0.04 | 0.774 |
| Phosphate | -0.02 | 0.828 | 0.14 | 0.260 |
| Alkaline phosphatase | 0.11 | 0.264 | -0.02 | 0.887 |
| Creatinine | 0.07 | 0.494 | -0.02 | 0.848 |
| LDL cholesterol | -0.03 | 0.746 | -0.30 | 0.014 |
| HDL cholesterol | -0.04 | 0.677 | -0.01 | 0.919 |
| Total cholesterol | -0.07 | 0.500 | -0.24 | 0.050 |
| Triglycerides | -0.07 | 0.484 | 0.00 | 0.992 |
| Lipoprotein(a) | 0.11 | 0.286 | 0.08 | 0.507 |
Data presented in study cohort patients (n=104). In 18F-FDG analyses, patients with failed myocardial suppression were excluded (n=33).