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. Author manuscript; available in PMC: 2019 Feb 7.
Published in final edited form as: Biochemistry. 2017 Feb 7;56(7):986–996. doi: 10.1021/acs.biochem.6b01093

Scheme 1.

Scheme 1

Two models for mammalian metabolism of H2S. In the model proposed by Jorns and coworkers (steps 1–5) sulfite acts as the sulfane sulfur acceptor in the SQOR reaction27,28. In an alternate model proposed by Libiad et al. (steps 6–9) glutathione is the acceptor in the SQOR reaction1. Steps 2 and 7 correspond to the forward and reverse directions, respectively, of the reversible TST reaction. SQOR, sulfide:quinone oxidoreductase; TST, thiosulfate sulfurtransferase; SDO, sulfur dioxygenase; SO, sulfite oxidase.