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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Curr Opin Nephrol Hypertens. 2019 Mar;28(2):120–127. doi: 10.1097/MNH.0000000000000477

Figure 3. Hypothesized second-messenger signaling cascade of Agtr1a within the SST3 subtype of Agrp neurons.

Figure 3.

Agtr1a within SST3 Agrp neurons may couple to a Gαi2 cascade that is sensitive to inhibition by the regulator of G protein signaling-2 (Rgs2), resulting in decreased intracellular cyclic adenosine monophosphate (cAMP) concentrations and repression of genes encoding the neurotransmitters Agouti-related peptide (Agrp), γ-aminobutyric acid (GABA), neuropeptide Y (Npy). This would disinhibit second-order neurons in the paraventricular nucleus, dorsomedial hypothalamus, lateral hypothalamic area, ventromedial hypothalamus and/or preoptic area, ultimately leading to the stimulation of resting metabolic rate (RMR).