Table 4.
Risk Factors Associated With Missed TB
| Clinical Factor | Univariate Analysis | Multivariate Analysisa | ||
|---|---|---|---|---|
| Unadjusted OR (95% CI) | P Value | Adjusted OR (95% CI) | P Value | |
| Age | 1.03 (1.01–1.05) | .003 | 1.03 (1.01–1.05) | .005 |
| Clinical symptoms or signs | ||||
| Cough or sputum | 0.72 (0.39–1.3) | .28 | — | |
| Weight loss | 0.45 (0.11–1.84) | .32 | — | |
| Abnormal image on chest x-ray | 1.51 (0.92–2.46) | .10 | — | |
| Underlying disease | ||||
| Hematologic malignancy | 1.93 (0.70–5.32) | .20 | 4.04 (1.27–12.90) | .02 |
| Solid tumor | 2.46 (1.44–4.19) | <.001 | 3.83 (1.95–7.52) | <.001 |
| Solid organ transplant | 0.92 (0.34–2.53) | .87 | 3.46 (1.05–11.37) | .04 |
| Underlying condition | ||||
| Neutropenia (ANC < 500/m3) | 3.79 (0.42–34.33) | .21 | — | |
| Steroid use | 1.93 (0.70–5.32) | .20 | — | |
| TNF-alpha blocker | 0.36 (0.07–1.89) | .27 | — | |
| Cytotoxic chemotherapy within 1 mo | 2.10 (1.07–4.12) | .03 | — |
Abbreviations: ANC, absolute neutrophil count; CI, confidence interval; OR, odds ratio; TB, tuberculosis; TNF, tumor necrosis factor.
aStatistically significant results were only presented in multivariate analysis.