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. 2016 May 20;75(6):482–498. doi: 10.1093/jnen/nlw033

FIGURE 1.

FIGURE 1

Dementia is associated with risk factors and pathologies that vary across the human aging spectrum. (A, B) Among the “oldest-old” with the clinical diagnosis of “Probable AD,” APOE ϵ4 alleles are decreasingly common after age 75 years (A) , whereas HS-Aging pathology is more prevalent with increasing age (p < 0.001 for both) in the NACC Data Set ( n  = 993 of subjects who died between 2005 and 2013) ( 57 ) (B) . Methodology for data analyses was as described previously ( 58 ). These data demonstrate the contribution to dementia of non- APOE genetic risk factors, and common non-AD pathologies in advanced old age.

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