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. 2016 May 20;75(6):482–498. doi: 10.1093/jnen/nlw033

FIGURE 3.

FIGURE 3

Both Alzheimer disease (AD) and primary age-related tauopathy (PART) are diagnosed based on a grid that incorporates pathologic staging information related to amyloid plaques and neurofibrillary tangles (NFTs). Shown is the grid for determining the level of AD neuropathologic changes at autopsy (2), based on Thal Aβ stages ( 89 ), CERAD neuritic amyloid plaque stages ( 90 ), and Braak NFT stages ( 91 ). Superimposed on the AD classification scheme are criteria for “Definite PART” (red) and “Possible PART” (yellow) ( 59 ) based on the same information.