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(A) Cytotoxicity of liposomal (●) DETA/NO and (▲) PAPA/NO as a function of NO payload against human Pa14c pancreatic cancer cells after 72 h of exposure. (B) Calculated LD50 values for (grey bars) DETA/NO and (black bars) PAPA/NO liposomes against pancreatic, breast, and colorectal cancer cell lines. Of note, the LD50 of PAPA/NO liposomes against Pa14c cells was >16.2 μg/mL. NO payloads were calculated based on the total amount of NO released from the liposomes over 72 h in PBS.
