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Chemoenzymatic cascade synthesis of pharmaceutically active GABA analogues. (A) Envisioned (chemo)enzymatic cascade synthesis of pharmaceutically active GABA analogues. Abbreviations: 4-OT*, newly engineered 4-OT variant that functions as a highly enantioselective artificial “Michaelase”; ALDH, aldehyde dehydrogenase; NR, nitroreductase. (B) Structures of GABA and its analogues pregabalin, phenibut, baclofen, and fluorophenibut.
