Table 5. Multivariate analysis and log-rank test for PFS and OS at interim and end-of-treatment PET/CT.

	Multivariate analysis
iPET4 (n = 181) 1st model	PFS			OS
Variables	Cox regression analysis		Log rank test	Cox regression analysis		Log rank test
	HR	95%CI	p-value	HR	95%CI	p-value
rDS	14.23	[3.56–56.86]	0.0002	5.23	[2.96–9.25]	<0.0001
ΔSUVmax	3.33	[1.36–8.17]	0.008	NS	–	>0.1
ΔSUVmax + rDS	6.86	[1.37–34.13]	0.019	NS	–	>0.1
Deauville score	NS	–	>0.1	NS	–	>0.1
Menton 2011 criteria	NS	–	>0.1	NS	–	>0.1
iPET4 (n = 181) 2nd model
rDS	4.46	[2.72–7.30]	<0.0001	2.71	[1.55–4.74]	0.0005
IPI score	2.54	[1.48–4.39]	0.0008	2.30	[1.19–4.46]	0.013
Chemotherapy	2.28	[1.16–4.49]	0.016	2.73	[1.19–6.24]	0.017
ΔSUVmax	NS	–	>0.1	NS	–	>0.1
Deauville score	NS	–	>0.1	NS	–	>0.1
PET-eot (n = 165)
rDS	8.11	[4.68–14.05]	<0.0001	6.50	[3.49–12.12]	<0.0001
IPI score	2.01	[1.11–3.65]	0.02	2.21	[1.07–4.55]	0.03
Deauville score	NS	–	>0.1	NS	–	>0.1
Chemotherapy	NS	–	>0.1	NS	–	>0.1

PFS: Progression Free survival; OS: Overall Survival; NS: Not Significant; rDS: ratio Deauville Score = Tumour/Liver SUVmax ratio

Menton 2011 criteria: ΔSUVmax if eligible patient and DS if SUVmax initial tumour <10 and / or if SUVmax residual tumour >5

ΔSUVmax + rDS: ΔSUVmax if eligible patient and rDS if SUVmax initial tumour <10 and / or if SUVmax residual tumour >5

IPI: International Prognostic Index.