Figure 4. Hepatic concentration of immunological mediators in C57BL/6 wild-type mouse livers at 14 weeks of age (8 weeks post DEN/TAA treatment) administered with serine-type protease inhibitors (STPIs) administered mice.

Tissue cytokine concentration: (A) granulocyte-monocyte colony stimulating factor (GM-CSF), (B) Tumor necrosis factor (TNF)-α, (C) Stem cell factor (SCF). (D) Expression (mRNA) levels of Lgr5 gene. (E) Changes in liver arginase activity in animals fed with STPIs. Results are expressed as mean ± SEM (4–6). ^*Indicates statistical differences (Tukey–Kramer’s test, P < 0.05) to DEN/TAA-treated animals not receiving STPIs.