Table 3. Association between rs10993994 polymorphism in MSMB gene and PC aggressiveness by alleles and according to different inheritance models.
| MSMB polymorphism | Controls (n = 628) | Gleason ≤ 6 | Gleason 7 | Gleason ≥ 8 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases (n = 82) | ORa | 95% CI | Cases (n = 114) | ORa | 95% CI | Cases (n = 116) | ORa | 95% CI | ||
| Alleles C T |
864 392 |
116 48 |
1.00 0.93 |
- 0.64–1.34 |
160 68 |
1.00 0.94 |
- 0.68–1.28 |
156 76 |
1.00 1.13 |
- 0.83–1.55 |
| Codominant CC CT TT |
314 236 78 |
40 36 6 |
1.00 1.29 0.59 |
- 0.79–2.11 0.24–1.47 |
63 34 17 |
1.00 0.74 1.06 |
- 0.46–1.17 0.58–1.93 |
54 48 14 |
1.00 1.38 1.07 |
- 0.88–2.16 0.55–2.08 |
| Dominant CC CT+TT |
314 314 |
40 42 |
1.00 1.10 |
- 0.69–1.77 |
63 51 |
1.00 0.82 |
- 0.54–1.24 |
54 62 |
1.00 1.30 |
- 0.85–1.97 |
| Recessive CC+CT TT |
550 78 |
76 6 |
1.00 0.53 |
- 0.22–1.28 |
97 17 |
1.00 1.19 |
- 0.67–2.12 |
102 14 |
1.00 0.92 |
- 0.49–1.73 |
aModels adjusted for age at interview, birthplace and family history of PC.