Table 4. Association between rs10993994 polymorphism in MSMB gene and PC onset by alleles and according to different inheritance models.
| MSMB polymorphism | Early onset PC | Late onset PC | |||||
|---|---|---|---|---|---|---|---|
| Controls (n = 628) | Cases (n = 55) | ORa | 95% CI | Cases (n = 267) | ORa | 95% CI | |
| Alleles C T |
864 392 |
72 38 |
1.00 1.43 |
- 0.88–2.33 |
371 163 |
1.00 1.00 |
- 0.79–1.26 |
| Codominant CC CT TT |
314 236 78 |
26 20 9 |
1.00 0.95 2.60 |
- 0.57–1.58 1.31–5.14 |
134 103 30 |
1.00 1.13 0.90 |
- 0.89–1.43 0.63–1.27 |
| Dominant CC CT+TT |
314 314 |
26 29 |
1.00 1.21 |
- 0.76–1.93 |
134 133 |
1.00 1.07 |
- 0.86–1.33 |
| Recessive CC+CT TT |
550 78 |
46 9 |
1.00 2.66 |
- 1.41–5.04 |
237 30 |
1.00 0.85 |
- 0.61–1.19 |
aModels adjusted for age at interview, birthplace, body mass index two years before interview or PC diagnosis and family history of PC.