Figure 7.
The effects of elastase inhibition on the migration of MDA-MB-231 cells. A) The effect of HNE on the migration of MDA-MB-231 cells. The cells were incubated with different concentrations of HNE for 48 h. B, C) The effects of loggerpeptin C (3) and molassamide (4) on the migration of MDA-MB-231 cells. MDA-MB-231 cells were incubated for 48 h with 100 nM HNE and different concentrations of 3 (B) and 4 (C). D) The effect of molassamide (4) on the migration of MDA-MB-231 cells in the absence of HNE. The effect on migration was compared to the solvent control. The asterisks denote significance of P < 0.05 relative to solvent control using two-tailed unpaired t test (** denotes P ≤ 0.01).