Table 3. Molecular characteristics of SMAD4m tumors.
| SMAD4m | SMAD4wt | P_value | ||
|---|---|---|---|---|
| Cases (N) | 28 | 56* | ||
| Genetic mutations | KRAS/NRAS | 22 (79%) | 29 (52%) | 0.0178 |
| TP53 | 13(46%) | 26 (46%) | NS | |
| APC | 11(39%) | 18 (32%) | NS | |
| PIK3CA | 3 (11%) | 14 (25%) | NS | |
| BRAF | 2 (7%) | 11 (20%) | NS | |
| FBXW7 | 2 (7%) | 5 (9%) | NS | |
| PTEN | 1 (4%) | 4 (7%) | NS | |
| ATM | 1 (4%) | 3 (5%) | NS | |
| CTNNB1 | 0 | 3 (5%) | NS | |
| Cases tested (N) | 22 | 54 | ||
| MMR by IHC | MSS | 20 (91%) | 40 (74%) | 0.103 |
| MSI-H | 2 (9%) | 14 (26%) |
* The control patient with two synchronous tumors had only transverse colon tumor sequenced.