Comparison 1. Ciprofloxacin (500 mg twice daily) versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to enter clinical remission at week 10 or 12	2	65	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.41, 0.92]
2 Failure to maintain clinical remission at week 24	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3 Failure to have a clinical response at week 10	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
4 Adverse events	2	65	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.57, 1.76]
5 Serious adverse events	1	18	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Withdrawal due to adverse events	2	65	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.07, 1.67]