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. 2018 Dec 17;211(2):503–513. doi: 10.1534/genetics.118.301817

Figure 2.

Figure 2

The loss of Rpd3L histone deacetylase suppresses the MMS sensitivity of checkpoint mutants. (A) The nonsense mutation rxt2-Q102STOP, and deletions in Rpd3 or the Rpd3L-specific component Sds3, but not the Rpd3S-specific component Rco1 or Eaf3, suppress the rad53∆ sensitivity to MMS. Strains: YJT72, YJT75, YBG245, YBG615, YBG369, YBG618, and YBG616. (B) Expression of Rpd3, but not rpd3-H150A histone deacetylase catalytically dead mutant, prevents the suppression by rpd3∆. Strains: YJT72+YEplac112, YJT75+YEplac112, YBG369+YEplac112, YBG369+YEplac112-Rpd3, and YBG369+YEplac112-rpd3-H150A.