Table 1. Chromosome loss in cells carrying high-copy TPKs, dam1-S31A, and dam1-S31D.

Genotype	Total colonies	Chromosome loss in first division (red/white half sectors)
1pRS426 CFIII	3544	8.47E−04 (3); 1
2pRS426-TPK1 CFIII	2972	5.72E−03 (17); 6.8× higher vs. pRS426
3pRS426-TPK2 CFIII	2516	9.94E−03 (25); 11.7× higher vs. pRS426
4pRS426-TPK3 CFIII	2972	6.06E−03 (18); 7.1× higher vs. pRS426
5pRS426-TPK2 dam1-S31A CFIII	4212	1.66E−03 (7); 1.9× higher vs. pRS426
6DAM1 CFIII	5582	1.25E−03 (7); 1
7dam1-S31A CFIII	6158	1.30E−03 (8); 1× higher vs. DAM1
8dam1-S31D CFIII	7996	2.38E−03 (19); 2× higher vs. DAM1

Numbers correspond to the following strains: 1–4 and 6 are in JCY534, 5 and 7 are in JCY1000, 8 is in JCY611.