Figure 6.

DIM-1 and heterochromatin machinery localize to heterochromatic regions and intergenic regions. (A) DamID Southern blots of genomic DNA of the indicated dim⁺ strains digested with DpnI (cuts GA^mTC; DI) or its isoschizomer DpnII (inhibited by adenine methylation; DII) or left undigested (−) and probed for the indicated regions. (B) DamID Southern blots, as in A, for different mutant backgrounds expressing the indicated DAM fusion constructs. (C) Table summarizing the phenotypes of a dim-1 strain. N.D., not determined.