Table 2. Joint analysis approaches for multiple G-E interactions in NHS I, NHS II, and HPFS cohorts.

	T2D	Obesity	Hypertension	CHD
	(P-value)	(P-value)	(P-value)	(P-value)
Univariatea	0.433	0.686	0.096	1.000
Omnibus	0.015b	0.003b	0.355	0.501
MultiE-uGRS	0.244	0.511	0.101	0.391
MultiE-wGRS	0.544	0.563	0.117	0.540
MultiSNP-ERS	0.051	0.208	0.006b	0.567
uGRS-ERS	0.473	0.037b	0.046b	0.576
wGRS-ERS	0.680	0.028b	0.021b	0.698

T2D, type 2 diabetes; CHD, coronary heart disease; uGRS, unweighted genetic risk score; wGRS, weighted genetic risk score; ERS, environmental risk score.

^aReported P-values were corrected for multiple testing by multiplying the total number of G-E interactions using the minimum P-value among the interactions: 0.002 (T2D), 0.002 (obesity), 0.0009 (hypertension), and 0.018 (CHD).

^bNominally significant interactions.