KEY RESOURCES TABLE
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| Rabbit polyclonal anti-TRPS1 | Bethyl | Cat # A303-563A; RRID: AB_10949357 |
| Rabbit polyclonal anti-p66 alpha | abcam | Cat # ab87663; RRID: AB_1952305 |
| Rabbit polyclonal anti-p66 beta | Bethyl | Cat # A301-283A; RRID: AB_937930 |
| Rabbit polyclonal anti-SNF2H | abcam | Cat # ab3749; RRID: AB_2191856 |
| Mouse monoclonal anti-alpha tubulin | Sigma-Aldrich | Cat # T9026; RRID: AB_477593 |
| Rabbit polyclonal anti-pHistone 3 (Ser 10) | Millipore | Cat # 06-570; RRID: AB_310177 |
| Rabbit polyclonal anti-MTA2 | abcam | Cat # ab8106; RRID: AB_306276 |
| Mouse monoclonal anti-HDAC2 | abcam | Cat # ab12169; RRID: AB_2118547 |
| Rabbit polyclonal anti-H3K27ac | Diagenode | Cat # C15410196; RRID: AB_2637079 |
| Mouse monoclonal anti-H3K27me3 | abcam | Cat # ab6002; RRID: AB_305237 |
| Chemicals, Peptides, and Recombinant Proteins | ||
| TransIT-293 Transfection Reagent | Mirus | Cat # MIR2700 |
| Polybrene | Millipore | Cat # TR-1003-G |
| Puromycin | InvivoGen | Cat # ant-pr-1 |
| Critical Commercial Assays | ||
| CellTiter-Glo Luminescent Cell Viability Assay | Promega | Cat # G7573 |
| ThruPLEX DNA-seq 48S Kit | Rubicon | Cat # R400427 |
| QIAamp DNA Blood Maxi kit | QIAGEN | Cat #51194 |
| QIAamp DNA Mini kit | QIAGEN | Cat # 51304 |
| RNeasy Mini Kit | QIAGEN | Cat# 74106 |
| Alexa Fluor 488 Annexin V/Dead Cell Apoptosis Kit | Life Technologies | Cat # V13241 |
| Deposited Data | ||
| Raw genomic data | NCBI GEO | GEO: GSE114600 |
| Experimental Models: Cell Lines | ||
| HEK293T cells | ATCC | Cat # CRL-11268 |
| 59 cancer cell lines used in the screen (Table S1) | various | N/A |
| HCC3153 shTRPS1-1 cells | This paper | N/A |
| HCC3153 shTRPS1-1 RFP-H2B cells | This paper | N/A |
| HCC3153 shTRPS1-2 cells | This paper | N/A |
| HCC3153 shTRPS1-2 RFP-H2B cells | This paper | N/A |
| Oligonucleotides | ||
| shTRPS1-1a: CCGGCTGAGGTCCTGACAAGCGATACTCGAGTATCGCTTGTCAGGACCTCAGTTTTT | This paper | N/A |
| shTRPS1-1b: AATTAAAAACTGAGGTCCTGACAAGCGATACTCGAGTATCGCTTGTCAGGACCTCAG | This paper | N/A |
| shTRPS1-2a: CCGGGAGGTCCTGACAAGCGATAACCTCGAGGTTATCGCTTGTCAGGACCTCTTTTT | This paper | N/A |
| shTRPS1-2b: AATTAAAAAGAGGTCCTGACAAGCGATAACCTCGAGGTTATCGCTTGTCAGGACCTC | This paper | N/A |
| Recombinant DNA | ||
| pRSI16cb-U6-sh-13kCB18-HTS6-UbiC-TagRFP-2A-Puro | McDonald et al., 2017 | Cellecta Cat # SVSHU616-L |
| 13K-hTF | McDonald et al., 2017 | Cellecta Cat # 13K-hTF-GH-NOVA |
| 13K-hEPI2 | McDonald et al., 2017 | Cellecta Cat # 13K-hEPI2-GHNOVA |
| Lentiviral Packaging Plasmid Mix | Cellecta | Cat # CPCP-K2A |
| Tet-pLKO-puro | Wiederschain et al., 2009 | Addgene Cat #21915 |
| pBABE-RFP-H2B | David Pellman (DFCI) | N/A |