. Author manuscript; available in PMC: 2019 Feb 7.

Published in final edited form as: Benef Microbes. 2018 Apr 10;9(3):345–355. doi: 10.3920/BM2017.0059

Table 3.

Relationship of Stool and Urine Trefoil Factor 3 (TFF3) to Intestinal Permeability Lactulose/Mannitol (L/M), Stool Shannon Diversity, Number of OTUs and Christensenellaceae in Females with Irritable Bowel Syndrome

	L/M ratio, night	Shannon Diversity^b	Number of OTUs^b	Christensenellaceae^b
Log of Stool TFF3
Simple correlation	−0.23^*	−0.28^*	−0.34^**	−0.37^**
Partial correlation^a	−0.24^*	−0.29	−0.36^**	−0.40^**
Simple correlation, among participants not using hormone contraceptive	−0.09	−0.27	−0.39^**	−0.34^*
Simple correlation, among participants using hormone contraceptive	−0.63^**	−0.30	−0.28	−0.61^**
Urine TFF3
Simple correlation	0.00	0.06	0.03	0.10
Partial correlation^a	0.05	0.14	0.13	0.19
Simple correlation, among participants not using hormone contraceptive	0.18	0.05	−0.06	−0.12
Simple correlation, among participants using hormone contraceptive users	0.07	0.30	0.34	0.46^*

Notes. TFF3 = Trefoil Factor 3; No Hormone Contraceptive (n = 36 to 46). Hormone Contraceptive (n = 19 to 24). For stool TFF3, n = 72 – 89.

Partial correlation controlling for hormone contraceptive. Pearson R was used.

Correlations with microbiome measures are partial correlations controlling for total read count.

p < 0.05

^**

p < 0.01