Table 2.

RR for OS, PFS, and EFS at 8 Years and Cumulative Incidences of CCyR, MMR, and CMR According to the Transcript Level at 3, 6, and 12 Months

Outcome	RR for Transcript Level (Log)		Cutoff (%)	No. of Patients at Risk	8-Year Probability of the Outcome		8-Year Probability of the Outcome According to Risk Group
	RR	P			%	P	No. of Patients	%	P
BCR-ABL1 transcript level at 3 months
OS	0.161	< .001				< .001
Low risk			≤ 9.84	211	93.3		N/A	N/A
High risk			> 9.84	68	56.9		N/A	N/A
PFS	0.162	< .001				< .001			< .001
Low risk			≤ 9.54	208	92.8		211	92.8
High risk			> 9.54	71	57.0		68	55.5
EFS	0.102	< .001				< .001			< .001
Low risk			≤ 9.84	211	65.1		211	65.1
High risk			> 9.84	66	6.9		66	6.9
CCyR	5.17	< .001				< .001			< .001
Low risk			≤ 8.58	169	99.4		180	97.9
High risk			> 8.58	79	21.7		68	14.8
MMR	12.98	< .001				< .001			< .001
Low risk			≤ 2.81	141	82.5		210	70.1
High risk			> 2.81	137	21.1		68	0
CMR	10.95	< .001				< .001			< .001
Low risk			≤ 0.61	57	84.7		211	19.3
High risk			> 0.61	222	1.5		68	0
BCR-ABL1 transcript level at 6 months
OS	0.342	< .001				< .001	N/A	N/A
Low risk			≤ 1.67	187	93.7		N/A	N/A
High risk			> 1.67	87	74.7
PFS	0.328	< .001				< .001			< .001
Low risk			≤ 1.73	188	92.8		187	92.8
High risk			> 1.73	86	68.9		87	69.4
EFS	0.195	< .001				< .001			< .001
Low risk			≤ 1.67	186	70.7		186	70.7
High risk			> 1.67	87	18.3		87	18.3
CCyR	5.033	< .001				< .001			< .001
Low risk			≤ 2.70	98	92.0		82	93.9
High risk			> 2.70	66	24.7		82	35.8
MMR						< .001			< .001
Low risk	6.854	< .001	≤ 0.73	136	81.6		176	72.5
High risk			> 0.73	123	20.4		83	13.9
CMR	4.405	< .001				< .001			.006
Low risk			≤ 0.21	73	42.7		187	21.0
High risk			> 0.21	197	6.1		83	4.0
BCR-ABL1 transcript level at 12 months
OS	0.398	< .001				< .001	N/A	N/A
Low risk			≤ 0.53	164	95.4		N/A	N/A
High risk			> 0.53	93	74.7
PFS	0.333	< .001				< .001			< .001
Low risk			≤ 0.53	164	94.9		164	94.9
High risk			> 0.53	92	73.1		92	73.1
EFS	0.280	< .001				< .001			< .001
Low risk			≤ 0.57	168	82.1		164	75.0
High risk			> 0.57	78	41.4		82	27.6
MMR	5.639	< .001				< .001			< .001
Low risk			≤ 0.22	90	81.6		121	78.4
High risk			> 0.22	114	20.4		83	12.3
CMR	4.139	< .001				< .001			.005
Low risk			≤ 0.036	59	52.1		158	18.8
High risk			> 0.036	182	4.1		83	4.1

NOTE. Table shows the cutoff in transcript levels that distinguishes low-risk and high-risk groups with maximal sensitivity and specificity for each outcome, the 8-year probability of outcome in each of the two groups created by applying the cutoffs identified for each outcome, and the 8-year probabilities for the various outcomes according to the risk group defined by OS.

Abbreviations: CCyR, complete cytogenetic response; CMR, complete molecular response; EFS, event-free survival; MMR, major molecular response; OS, overall survival; PFS, progression-free survival; RR, relative risk.