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. 2019 Jan 23;11(2):590–614. doi: 10.18632/aging.101762

Table 7. GO analysis of aging-related differentially expressed genes.

Expression Term Gene function Gene count Enrichment score P -value
Down GO:0060330 Regulation of response to interferon-gamma 3 89.23 0
Down GO:0051607 Defense response to virus 54 14.34 1.3E-46
Down GO:0060337 Type I interferon signaling pathway 33 19.25 6.2E-34
Down GO:0045071 Negative regulation of viral genome replication 22 20.88 2.1E-24
Down GO:0009615 Response to virus 30 11.74 3.4E-24
Down GO:0045087 Innate immune response 50 5.49 4.8E-23
Down GO:0060333 Interferon-gamma-mediated signaling pathway 27 12.29 1.4E-22
Down GO:0035455 Response to interferon-alpha 13 31.35 2.0E-18
Down GO:0035456 Response to interferon-beta 9 24.34 2.1E-12
Down GO:0032480 Negative regulation of type I interferon production 11 14.02 2.1E-11
Down GO:0003725 Double-stranded RNA binding 15 7.65 1.8E-10
Down GO:0050897 Cobalt ion binding 5 27.88 1.4E-08
Down GO:0042296 ISG15 transferase activity 4 39.66 2.1E-08
Down GO:0004386 Helicase activity 14 5.68 3.6E-08
Down GO:0004694 Eukaryotic translation initiation factor 2alpha kinase activity 4 35.69 4.2E-08
Down GO:0042406 Extrinsic component of endoplasmic reticulum membrane 5 23.48 4.6E-08
Down GO:0005829 Cytosol 147 1.48 1.6E-07
Down GO:0016020 Membrane 96 1.66 2.5E-07
Down GO:0046696 Lipopolysaccharide receptor complex 3 26.77 3.1E-06
Down GO:0032183 SUMO binding 5 11.74 3.9E-06
Down GO:0044530 Supraspliceosomal complex 3 24.33 4.8E-06
Down GO:0005730 Nucleolus 45 1.98 6.1 E-06
Down GO:0003726 Double-stranded RNA adenosine deaminase activity 3 22.31 7.2E-06
Down GO:0003836 Beta-galactoside (CMP) alpha-2,3-sialyltransferase activity 4 11.51 2.3E-05
Down GO:0003727 Single-stranded RNA binding 6 6.86 2.8E-05
Down GO:0008253 5'-Nucleotidase activity 4 10.82 3.2E-05
Down GO:0005737 Cytoplasm 207 1.24 0.0001
Down GO:1990130 Iml1 complex 3 9.91 0.0002
Down GO:0000784 Nuclear chromosome, telomeric region 9 3.40 0.0004
Down GO:0030670 Phagocytic vesicle membrane 6 3.88 0.0010
Up GO:0015728 Mevalonate transport 3 81.66 0
Up GO:0051780 Behavioral response to nutrient 3 81.66 0
Up GO:0015130 Mevalonate transmembrane transporter activity 3 81.66 0
Up GO:0014731 Spectrin-associated cytoskeleton 10 9.07 1.5E-08
Up GO:0097159 Organic cyclic compound binding 3 61.24 2.2E-08
Up GO:0060318 Definitive erythrocyte differentiation 3 61.24 2.2E-08
Up GO:0030056 Hemidesmosome 8 10.54 6.7E-08
Up GO:0006275 Regulation of DNA replication 8 10.05 1.0E-07
Up GO:0031581 Hemidesmosome assembly 8 9.47 1.7E-07
Up GO:0031640 Killing of cells of other organism 4 18.15 2.0E-06
Up GO:0030334 Regulation of cell migration 12 4.54 3.2E-06
Up GO:0021801 Cerebral cortex radial glia guided migration 4 16.33 3.6E-06
Up GO:0005833 Hemoglobin complex 4 20.41 1.1E-06
Up GO:0016528 Sarcoplasm 6 10.42 1.6E-06
Up GO:0046898 Response to cycloheximide 3 24.50 4.4E-06
Up GO:0071839 Apoptotic process in bone marrow 3 24.50 4.4E-06
Up GO:0008091 Spectrin 7 7.33 5.3E-06
Up GO:0031301 Integral component of organelle membrane 4 13.61 9.5E-06
Up GO:0043034 Costamere 9 5.10 1.2E-05
Up GO:0045111 Intermediate filament cytoskeleton 11 4.20 1.5E-05
Up GO:0030424 Axon 24 2.49 1.8E-05
Up GO:0097136 Bcl-2 family protein complex 3 16.33 2.7E-05
Up GO:0030507 Spectrin binding 9 4.65 2.8E-05
Up GO:0030506 Ankyrin binding 8 5.03 3.5E-05
Up GO:0051434 BH3 domain binding 3 15.31 3.6E-05
Up GO:0042803 Protein homodimerization activity 37 1.94 5.5E-05
Up GO:0050840 Extracellular matrix binding 5 7.29 6.4E-05
Up GO:0005200 Structural constituent of cytoskeleton 14 3.04 7.5E-05
Up GO:0005539 Glycosaminoglycan binding 4 8.83 8.5E-05
Up GO:0098641 Cadherin binding involved in cell-cell adhesion 24 2.19 0.0001