Table 3. Univariate and multivariate Cox proportional hazards regression analyses in the primary cohort.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Hazard ratios (95%CI) | P-value | Hazard ratios (95%CI) | P-value | |
| Age | 1.029(1.016-1.042) | <0.001 | 1.031(1.017-1.045) | <0.001 |
| T stage | ||||
| T1 | Referent | |||
| T2 | 1.620(1.037-2.530) | 0.034 | ||
| T3 | 1.623(0.911-2.889) | 0.100 | ||
| T4 | 4.402(2.194-8.830) | <0.001 | ||
| N stage | ||||
| N0 | Referent | |||
| N1 | 2.035(1.350-3.069) | 0.001 | ||
| N2 | 2.977(1.745-5.081) | <0.001 | ||
| N3 | 4.246(2.287-7.882) | <0.001 | ||
| Unknown | 7.666(3.001-19.582) | <0.001 | ||
| TNM stage | ||||
| I | Referent | Referent | ||
| II | 2.011 | 0.021 | 2.142(1.179-3.893) | 0.012 |
| III | 3.269 | <0.001 | 3.850(2.042-7.256) | <0.001 |
| IV | 12.784 | <0.001 | 15.909(7.474-33.865) | <0.001 |
| ER status | ||||
| Negative | Referent | Referent | ||
| Positive | 0.652(0.444-0.958) | 0.029 | 0.508(0.342-0.754) | 0.001 |
| Unknown | 1.918(0.921-3.997) | 0.082 | 1.755(0.837-3.678) | 0.137 |
| PR status | ||||
| Negative | Referent | |||
| Positive | 0.737(0.498-1.090) | 0.127 | ||
| Unknown | 1.260(0.757-2.098) | 0.374 | ||
| HER2 status | ||||
| Negative | Referent | |||
| Positive | 1.288(0.778- 2.134) | 0.325 | ||
| Unknown | 1.459(0.969-2.196) | 0.071 | ||
| Six-miRNA signature | 1.194(1.140-1.252) | <0.001 | 1.193(1.138-1.251) | <0.001 |
Notes: Bold values indicate statistical significance (P<0.05). CI, confidence interval, ER, estrogen receptor; PR, progestrone receptor; HER2, human epithelial growth factor receptor 2.