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. 2019 Jan 18;11(2):386–400. doi: 10.18632/aging.101743

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Copyright © 2019 Jadeja et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Absence of GPR109A induces age-associated hepatic steatosis in mice. (A) Morphological appearance (1-2), hematoxylin and eosin (3-4) and Oil red O staining of 12 month old WT and Gpr109a^-/- mouse liver sections (20X) (5-6). (B) Changes in liver weight and (C) triglyceride content of 12-month-old WT and Gpr109a^-/- mice. (D) Semi-quantitative scoring system was used to assess hepatocyte steatosis (0, 1-5% of total area; 1, 5 – 33% of the total area; 2, 33 – 66% of the total area; 3, >66% of the total area; results represented in arbitrary units. (E-F) Changes in the circulating levels of liver injury markers. Data is represented as mean ± S.E.M for (n=6). *p<0.05 vs. WT.