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. 2019 Jan 18;11(2):386–400. doi: 10.18632/aging.101743

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Copyright © 2019 Jadeja et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Increased lipogenesis and decreased lipolysis accounts for hepatocyte fat accumulation in Gpr109a^-/- mice. (A-F) mRNA expression of genes regulating hepatocyte lipid metabolism was performed by qPCR assay. Data are presented as mean ± S.E.M for (n=4). *p<0.05 vs. WT. SREBP1c; sterol regulatory element-binding transcription factor 1, FAS; fatty acid synthase, ACC; acetyl-CoA carboxylase, PPARα; peroxisome proliferator-activated receptor alpha, ACOX-1; Acyl-CoA Oxidase 1, CPT1A; Carnitine palmitoyltransferase IA.