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. 2019 Jan 16;11(2):448–466. doi: 10.18632/aging.101751

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Copyright © 2019 Duan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Biological processes and hub genes related to mitochondrial functions in CAVS. (A) Co-expression network approaches to reveal hub genes associated with mitochondrial functions in CAVS; (B) a. overview of hub genes and connected miRNAs. b. subnetwork of the integrated miRNAs and hub genes. The triangle and dot represent the hub genes and miRNA, respectively. Red color and up-direction represent up-regulated hub genes, blue color and down-direction represent down-regulated hub genes. The size color saturation of the nodes was weighted by the connectedness of the hub gene interacted with other miRNAs. c. two tail T-test of top-ten hub genes expression based on data profiles; C. Real-time PCR results of mRNA expression of these top-ten hub genes based on clinical samples; D. Western Blot results of protein expression of these top-ten hub genes based on clinical samples; *P<0.05, **P<0.01.