Table 2. Univariate and multivariate analyses of miR-223-3p and SLC4A4 mRNA level and patient overall survival.

	Univariate analysis			Multivariate analysisc
Variable	HRa	95%CIb	P	HRa	95% CIb	P
Overall survival (n = 500)
Age (years)
>60 (n = 249)	1.804	1.322-2.462	0.000*	1.683	1.231-2.300	0.001*
≤60 (n = 251)
Sex
Male (n = 327)	0.917	0.671-1.254	0.588
Female (n = 173)
T stage
T3 or T4 (n = 185)	2.930	2.155-3.983	0.000*	1.628	1.137-2.333	0.008*
T1 or T2 (n = 315)
N stage
N1 (n = 14)	3.500	1.842-6.648	0.000*
N0 or NX (n =486)
M stage
M1 (n = 77)	4.201	3.069-5.749	0.000*	2.706	1.886-3.883	0.000*
M0 or MX (n = 423)
Grade
G3 or G4 (n = 273)	2.602	1.840-3.679	0.000*	1.584	1.092-2.298	0.015*
G1 or G2 (n = 227)
miR-223-3p
High (n = 250)	2.130	1.553-2.921	0.000*	1.888	1.371-2.599	0.000*
Low (n = 250)
SLC4A4
High (n = 250)	0.558	0.409-0.761	0.000*	0.642	0.470-0.878	0.005*
Low (n = 250)

^aHazard ratio, estimated from Cox proportional hazard regression model.

^bLower and upper confidence interval of the estimated HR.

^cMultivariate models were adjusted for T, N, M classification, age and sex.

HR hazard ratio, CI confidential interval, T stages Tumor stage, N stage lymphatic metastasis, M stage distant metastasis